Checkpoint Therapeutics Inc

Checkpoint Therapeutics Inc. a clinical-stage immunotherapy and targeted oncology company focuses on the acquisition development and commercialization of novel treatments for patients with solid tumor cancers. The company's lead antibody product candidate is Cosibelimab a fully-human monoclonal antibody of IgG1 subtype that directly binds to programmed death ligand-1 (PD-L1) and blocks the PD-L1 interaction with the programmed death receptor-1 and B7.1 receptors; and CK-302 a human agonistic antibody that is designed to bind to and trigger signaling in GITR expressing cells. It is also developing Olafertinib a third-generation epidermal growth factor receptor (EGFR) inhibitor as a treatment for patients with EGFR mutation-positive non-small cell lung cancer; CK-103 a selective and potent small molecule inhibitor of bromodomain and extra-terminal bromodomains; and anti-carbonic anhydrase IX (CAIX) antibody a fully human preclinical antibody to recognize CAIX expressing cells and kill them via antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity. The company has collaboration agreements with TG Therapeutics Inc. to develop and commercialize certain assets in connection with its licenses in the field of hematological malignancies. The company was incorporated in 2014 and is based in Waltham Massachusetts. Checkpoint Therapeutics Inc. is a subsidiary of Fortress Biotech Inc.