AC Immune SA

AC Immune SA a clinical stage biopharmaceutical company discovers designs and develops medicines and diagnostic products for the prevention and treatment of neurodegenerative diseases associated with protein misfolding. Its SupraAntigen and Morphomer platforms are designed to generate vaccines antibodies and small molecules which selectively interact with misfolded proteins that are common in a range of neurodegenerative diseases. The company is developing Crenezumab a humanized conformation-specific monoclonal antibody which is in Phase II clinical studies trial for the treatment of Alzheimer's disease (AD). It is also developing ACI-24 an anti-Abeta vaccine candidate that is in Phase II clinical study for AD as well as completed Phase Ib clinical study for Down syndrome; ACI-35 an anti-Tau vaccine candidate that is in Phase Ib/2a clinical study; and Tau- positron emission tomography (PET) imaging tracer which is in Phase II clinical study. In addition the company is researching and developing small molecule Tau aggregation inhibitors for AD and NeuroOrphan indications. Further it has discovery and preclinical stage molecules targeting range of neurodegenerative diseases which include diagnostics targeting TDP-43 alpha-synuclein and NLRP3. AC Immune SA has license agreements and collaborations with Genentech Inc.; Biogen International GmbH; Janssen Pharmaceuticals Inc.; Life Molecular Imaging SA; Eli Lilly and Company; and WuXi Biologics. The company was incorporated in 2003 and is headquartered in Lausanne Switzerland.